A large-scale RNAi screen in human cells identifies new components of the p53 pathway
Article Abstract:
For the purpose of performing loss-of-function genetic screens in lower organisms, RNA interference (RNAi) which is considered to be a powerful tool is developed. These new tools are expected to facilitate the large-scale loss-of-function genetic screens, in mammalian cells.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
United States, Human genetics, Cell research, Cytological research, RNA interference
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation
Article Abstract:
Research has been conducted on proliferating cell nuclear antigen. The authors have demonstrated that RAD6-mediated mono-ubiquitization of proliferating cell nuclear antigen activates translesion DNA synthesis via damage-tolerant polymerases nu and zeta in yeast.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
Germany, Analysis, Physiological aspects, Genetic aspects, DNA repair, Eukaryotes, Microbiology, Proteins, Genetic regulation, Cell proliferation, Yeast fungi, Yeasts (Fungi), Ubiquitin, Mutagenesis, Antigens, DNA synthesis
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
Subjects list: Research
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