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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

MISSION(super TM) shRNA library: Next generation RNA interference

Article Abstract:

Sigma-Aldrich assist the development, manufacturing and global distribution of The RNA interference Consortium's human and mouse lentiviral vector-based shRNA libraries (MISSION(super TM) shRNA) and it is committed to providing unmatched infrastructure and service for RNA interference research needs. Approximately 50,000 clones targeting 7,100 human and 2,900 mouse genes are available and the libraries include a broad range of gene families, functional classes, and druggable targets.

Author: Uder, Stephanie, George, Henry, Boedeker, Betsy
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
Genetic research

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RNAi-mediated gene silencing in non-human primates

Article Abstract:

RNA interference (RNAi)-mediated silencing in response to systemic delivery of small interfering RNA in non-rodent species is presented. The results show clinically relevant RNAi-mediated gene silencing in non-human primates, supporting RNAi therapeutics as a potential new class of drugs.

Author: Harborth, Jens, Koteliansky, Victor, Soutschek, Jurgen, Toudjarska, Ivanka, Manoharan, Muthiah, Jeffs, Lloyd B., MacLachlan, Ian, Judge, Adam D., Sood, Vandana, McClintock, Kevin, Bumcrot, David, John, Matthias, Akinc, Akin, Bramlage, Birgit, Rohl, Ingo, Racie, Timothy, Vornlocher, Hans-Peter, Zimmermann, Tracy S., Fedoruk, Matthew N., Lee, Amy C.H., Lam, Kieu, Heyes, James A., Seiffert, Stephan, Wheat, Amanda J., Yaworski, Ed, Nechev, Lubomir V., Shanmugam, Sumi, Zedalis, William, Palmer, Lorne R.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
Primates

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RNA interference is an antiviral defense mechanism in Caenorhabditis elegans

Article Abstract:

The RNA interference is a sequence specific post-transcriptional gene silencing mechanism that is genetically defined in Caenorhabditis elegans. RNA is proposed to function as an adaptive antiviral immune mechanism.

Author: Wilkins, Courtney, Dishongh, Ryan, Moore, Steve C., Whitt, Micheal A., Chow, Marie, Machaca, Khaled
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
Caenorhabditis elegans

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Subjects list: Research, United States, Gene silencing, RNA interference, Genetic aspects
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