Meiotic cell cycle requirement for a fly homologue of human Deleted in Azoospermia
Article Abstract:
The cloning and characterization of the Drosophila gene, boule, supports the hypothesis that Deleted in Azoospermia (DAZ) is the human Azoospermia factor. Boule and DAZ are responsible for the essential meiotic function in fly and human spermatogenesis, respectively. Boule resembles Azoospermia factor (AZF) in loss of function. It is similar to Deleted in Azoospermia (DAZ) in both testes-specific expression and amino-acid sequence. Histological analysis of boule testes with cell-cycle markers locates the defect at the meiotic G2/M transition.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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An atypical topoisomerase II from archaea with implications for meiotic recombination
Article Abstract:
The Saccharomyces cerevisiae protein Spo11 protein catalyzes the formation of double-strand breaks which initiate meiotic recombination in S. cerevisiae. This was gleaned from a comparison of the amino acid's mechanism of action with that of known type II topoisomerases as part of the study of genes encoding the A and B subunits of topoisomerase II from the archaeon Sulfolobus shibatae.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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