Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus
Article Abstract:
Analysis of an inhibitor of insulin-receptor tyrosine kinase, which is present in skin fibroblasts of insulin-resistant patients, reveals it as a membrane glycoprotein, PC-1. Out of nine patients with non-insulin-dependent diabetes mellitus, seven patients have significant PC-1 activity in fibroblasts. Insulin-induced tyrosine kinase activity is decreased by the overexpression of PC-1 in transfected cultured cells, suggesting the vital role of PC-1 in the insulin-resistance of non-insulin-dependent diabetes mellitus.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Gene therapy for rats and mice
Article Abstract:
Genetic engineering has been used to produce an analogue of insulin that has been inserted, via an insulin-encoding gene, into diabetic mice and rats. The animals were then able regulate their blood-sugar levels for eight months.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue
Article Abstract:
A new approach to gene therapy may aid the treatment of diabetes. A single-chain analogue of insulin has been expressed in liver cells using a recombinant adeno-associated virus controlled by a glucose-regulated promoter.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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