Nanog promotes transfer of pluripotency after cell fusion

Article Abstract:

Study is presented to investigate whether a variant homeodomain protein Nanog might facilitate transfer of pluripotency to neutral stem (NS) cell nuclei in the context of cell fusion. The findings show that Nanog could orchestrate embryonic stem (ES) cell machinery to instate pluripotency with an efficiency of up to 100% depending on the differentiation status of the somatic cell.

United States, Cell hybridization, Somatic cells

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Nanog safeguards pluripotency and mediates germline development

Article Abstract:

The fluctuations of Nanog, the key part of the pluripotent transcriptional network, in mouse embryonic stem cells are presented. It is inferred that the Nanog acts mainly in the development of inner cell mass and germ cell states, maintenance of pluripotency and that it balances embryonic stem cells in culture by resisting or reversing alternative gene expression states.

Gene expression, Mutation (Biology), Mutation, DNA binding proteins

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Fusion brings down barriers

Article Abstract:

How tissue-specific stem cells could generate the mature cell types of another tissue remains uncertain. In one instance, cell fusion is the solution, where bone-marrow-derived stem cells repair damaged liver in mice.

Genetic aspects, Bone marrow cells, Mice as laboratory animals, House mouse, Tissue engineering

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