Oligomerization activates c-Raf-1 through a Ras-dependent mechanism
Article Abstract:
The oligomerization of the c-Raf-1 proto-oncoprotein by a Ras-dependent mechanism facilitates Raf activation. The addition of FK506 derivatives of FK1012A induces the oligomerization of recombinant FKBP-Raf in situ, which stimulates Raf kinase activity almost half as well as the epidermal growth factor. This activation of FKBP-Raf is dependent upon Ras-GTP, which translocates c-Raf-1 to the membrane, initiating an alteration that facilitates the interaction of the Raf polypeptide with an activator.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity
Article Abstract:
The cRaf-1 protein kinases is mitogen-activated and is the main effector used by GTP-bound Ras to activate the MAP kinase pathway. GTP bound Ras can bind Raf but is not sufficient for the stable activation of Raf. The role of 14-3-3 proteins in the regulation of Raf's kinase activity is investigated. It is proposed that dimeric 14-3-3 is required to maintain Raf in the inactive state in the absence of GTP-bound Ras, and to stabilize active Raf.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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A signal for Beta-cell failure
Article Abstract:
Human type 2 diabetes is usually accompanied by insulin response defects, resulting in hyperglycaemia. Withers and colleagues have reported the phenotype of mice lacking alleles encoding the insulin-receptor substrate protein-2, IRS-2. The mice develop a syndrome like the common form of human type 2 diabetes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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