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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Crystal structure of human cytochrome P450 2C9 with bound warfarin

Article Abstract:

The crystal structure of a human cytochrome CYP450, CYP2C9 both unliganded and in complex with the anti-coagulant drug warfarin is described. The structure defines new binding pocket, and this binding mode of warfarin suggests that CYP2C9 may undergo an allosteric mechanism during its function.

Author: Jhoti, Harren, Williams, Pamel A, Cosme, Jose, Ward, Alison, Angove, Hayley C, Vinkovic, Dijana Matak
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
Cytochromes

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alpha-Neurexins couple Ca (super)2+ channels to synaptic vesicle exocytosis

Article Abstract:

Research has been conducted on alpha-neurexins which link synapses's pre- and postsynaptic compartments. The authors demonstrate that alpha-neurexins functionally couple Ca (super)2+ channels to the presynaptic machinery.

Author: Sudhof, Thomas C., Hammer, Robert E., Missler, Markus, Weiqi Zhang, Rohlmann, Astrid, Kattenstroth, Gunnar, Gottmann, Kurt
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
Germany, Biochemistry, Research and Development in the Physical, Engineering, and Life Sciences, Analysis, Physiological aspects, Genetic aspects, Calcium channels, Neurons, Molecular genetics, Neurotransmitters, Synapses, Exocytosis

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Subjects list: Research, United States
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