Pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila
Article Abstract:
A new segment polarity gene, pangolin, is identified using genetic methods in Drosophila. It is found that this gene encodes a homologue of the vertebrate transcription factor Lef-1/XTcf-3, and that its product is necessary to mediate Wnt/Wingless (Wg) signal transduction in vivo in embryos and in developing adult tissues. Genetic and molecular evidence illustrates that pangolin's transducing activity is influenced by direct associations with the beta-catenin homologue Armadillo. Findings also indicate that pangolin acts even lower than Armadillo in the Wg transduction pathway.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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A Roundabout way of avoiding the midline
Article Abstract:
It has been established that, in bilaterally symmetrical animals, a common mechanism determines which axons cross the midline and which do not. Recent research has identified a family of putative receptors for a short-range attractive signal from the midline. This is the Roundabout (Robo) family. To date, two robo genes have been identified in flies, along with two in the rat, one in worms and two in humans. Further research must address issues including the nature of the Robo ligand, the putative midline repellent.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Raf functions downstream of Ras1 in the Sevenless signal transduction pathway
Article Abstract:
Raf serine/threonine kinase of the Drosophila acts upstream of the sina gene and downstream of the Ras 1 gene in the transduction of signals toward the nucleus in the R7 pathway. R7 cell development can be induced by a constitutively activated Raf protein, with no sev function present. Response to the activity of the Sevenless receptor in the R7 pathway is dependent on raf function.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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