Pictures of MHC restriction

Article Abstract:

Cytolytic T lymphocytes have the ability to detect viral infection by identifying viral antigens found at the surface of the cell combined with major histocompatibility complex (MHC) class I glycoproteins. This phenomenon called MHC restriction arises from direct interaction between the viral antigen and class I MHC molecule through small peptide fragments. The extracellular part of the T-cell receptor comprises of alpha- and beta-chains, which have constant and variable domains. Three complementarity-determining regions interact with the MHC molecule.

Physiological aspects, Observations, T cells, Immunological research, Immunologic research, Viral antigens

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Flying the first class flag

Article Abstract:

New research confirms the role of genes within the major histocompatibility complex (MHC) in regulating peptide transport and antigen presentation. S.J. Powis and colleagues demonstrated that the polymorphism of a transporter gene in rats controls both the peptides loaded by a class I MHC molecule and the presenting of antigens. The transporter-protein controlled by the gene has such an intricate structure that it may have significant influence on immunological reactions.

Genetic aspects, Peptides, Antigens, Immunogenetics

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The duck's dilemma

Article Abstract:

Analyses of the molecular biology of the bifunctional protein and its antibodies in ducks show that bifunctional antibodies produce smaller species that binds antigen but does not summon effectors, followed by the trimming of two domains of the constant immunoglobin region. Alternative splicing of messenger RNA is suspected to be responsible for this mysterious molecular biology of ducks.

Molecular biology, Ducks

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