Low fidelity DNA synthesis by human DNA polymerase-eta
Article Abstract:
Polymerase-eta is thought to have relaxed discrimination ability. A new study tests this theory and investigates low fidelity DNA synthesis by human DNA polymerase-eta.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelity
Article Abstract:
The efficiency and fidelity of dimer bypass are determined. It is shown that polymerase eta (Pol eta) copies thymine dimers and the flanking bases with higher processivity than it copies undamaged DNA, and then shifts to less processive synthesis. Errors made by Pol eta during dimer bypass could contribute to mutagenesis and skin cancer.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta
Article Abstract:
It has been possible to isolate a DNA polymerase from HeLa cells that continues replication on damaged DNA by bypassing ultra-violet induced thymine dimers in xeroderma pigmentosum variant (XP-V) cell extracts. In all the XP-V cells analyzed, there was found to be decreased expression and/or severe mutation of the DNA polymerase eta gene. This suggests that mutations in this gene cause the defects in XP-V cells. The cDNA coding for the dimer-bypass DNA polymerase was concluded to be human DNA polymerase eta.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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