Playing upon both sides

Article Abstract:

Superantigens both aid and hinder the body's immunological defenses against infection by viruses such as the mouse mammary tumor retrovirus (MMTV). Superantigens strengthen the immune response by binding to class II major histocompatibility complex molecules, which in turn produce infection-fighting T cells with particular V-beta chains. However, superantigens also make T cells more vulnerable to infection by MMTV. The dual role of superantigens is prompting microbiologists and immunologists to collaborate in researching them.

Physiological aspects, Immune response, Oncogenic viruses, Antigens

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Osteopetrosis in mice lacking haematopoietic transcription factor PU.1

Article Abstract:

Mice lacking the hematopoietic transcription factor PU.1 exhibit arrested development of both osteoclasts and macrophages. Bones of PU.1-deficient mice failed to resorb cartilaginous bars and appositional bone and were devoid of osteoclasts, all of which are pathognomonic histological features of osteopetrosis. The absence of both osteoclasts and macrophages in PU.1-deficient mice indicates that the transcription factor may play a role in the initial stages of myeloid differentiation.

Osteopetrosis, Hematopoietic growth factors

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