Adherens junctions inhibit asymmetric division in the Drosophila epithelium

Article Abstract:

Research is presented concerning the asymmetric division which takes place among neural progenitor cells within the central nervous system of Drosophila flies. The conversion of symmetric division into asymmetric division is discussed.

Author: Jan, Lily Y., Bingwei Lu, Roegiers, Fabrice, Yuh Nung Jan
Central nervous system, Cell division, Letter to the Editor

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Primary structure and functional expression of mouse inward rectifier potassium channel

Article Abstract:

Expression cloning in Xenopus oocytes was used to isolate a complementary DNA encoding an inward rectifier K+ (IRK1) channel from a mouse macrophage cell line. This ion channel was characterized with respect to physiological functions and biophysical properties. Furthermore, sequence homology between the IRK1 channel and an ATP-regulated K+ channel provides information about channel structure and function.

Author: Jan, Lily Y., Yuh Nung Jan, Kubo, Yoshihiro, Baldwin, Timothy J.
Mice, Mice (Rodents), Macrophages, Potassium channels

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Asymmetric segregation of Numb and Prospero during cell division

Article Abstract:

A study conducted on Drosophila neuroblasts shows that Numb, a membrane-associated protein, and Prospero, a nuclear protein, are present near one centrosome from late prophase to end of telophase and are passed to one daughter cell only. Numb and Prospero localization is coupled to mitosis, independent of microtubules and actin, and highly correlated with the position of one of the two centrosomes. The organizer of asymmetric cell division provides positional information for the orientation of the mitotic spindle and asymmetric localization of Numb and Prospero.

Author: Jan, Lily Y., Yuh Nung Jan, Knoblich, Jurgen A.
Observations, Membrane proteins, Mitosis

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Subjects list: Research, Physiological aspects, Drosophila
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