Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease

Article Abstract:

Ciliary neurotrophic factor (CNTF) is a potential therapeutic agent for a primate model of Huntington's disease, which results from the degeneration of striatal neurons whose prevention or slowing has no effective treatment. Cell loss in the brains of monkeys induced by injections of quinolinic acid mimics the pathology of Huntington's disease. An evaluation of CNTF as a neuroprotective agent in the disease's primate model shows that human CNTF prevents much of the neural degeneration and raises the possibility that it may help prevent the degeneration of vulnerable populations of nerve cells in humans.

Health aspects, Analysis, Neurons, Neurotrophic functions, Neurotrophins

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Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

Article Abstract:

The autosomal-dominant progressive neurodegenerative disorder Huntington's disease leads to specific neuronal loss and dysfunction in the striatum and cortex. There is a lack of understanding about the molecular pathways mediating the neuropathology of Huntington's disease. Evidence of caspase-1 activation in the brains of mice and humans with the disease has been demonstrated, and it is shown that intracerebrovenricular administration of a caspase inhibitor delays progression and mortality in the mouse model.

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Delaying the onset of Huntington's in mice: This unremitting disease develops later in animals stimulated by their environment

Article Abstract:

Exposure of transgenic mice, created to develop a neurodegenerative syndrome similar to Huntington's disease, to a stimulating environment from an early age, helped to delay the onset of motor disorders, and prevent loss of cerebral volume.

Physiological aspects, Genetically modified mice

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