Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers
Article Abstract:
The charged sodium-channel blockers can be targeted into nociceptors by applying TRPV1 agonists in order to produce a pain-specific local anesthesia. Injection of QX-314 together with capsaicin into rat has produced a long-lasting increase in mechanical and thermal nociceptive thresholds, but has not shown any motor or tactile defects.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Voltage-sensor activation with a tarantula toxin as cargo
Article Abstract:
The kinetics and state dependence of the toxin-channel interaction and the physical location of the toxin in the membrane are examined. The formation of a strong and stable complex of voltage sensors with hanatoxin and the reduction of toxic-affinity is observed due to voltage-sensor activation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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