Recitative and aria

Article Abstract:

Recent advances in molecular biology techniques have allowed the purification of glial growth factors (GGF), neu differentiation factors (NDFs) and acetylcholine-receptor-inducing activity (ARIA) factors, and the cloning of thegene coding for them. The evidence indicates that all these trophic factors arecoded for by a single gene whose transcripts are processed differentially. The GGF/NDF/ARIA mRNAs are products of neurons which are expressed at early stages of embryonic neural development. Further research is required to sort out the activities associated with each trophic factor isoform.

Physiological aspects, Growth factors, Cell differentiation, Cell interaction, Cell interactions

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Unwrapping myelination

Article Abstract:

Biologist L. Shapiro and his colleagues have reported an X-ray crystal structure, to a resolution of 1.9 angstrom, for the extracellular domain of protein zero. The crystal structure is in good agreement with earlier predictions and it consists of a series of 10 antiparallel beta-strands arranged into two facing beta-sheets. Its tertamer, which resembles a square-shaped doughnut with a large central hole, interacts with the outside surfaces of four other tetrameric doughnuts connected to the apposed membrane surface.

Myelin proteins, Protein structure, Myelination

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A relative signalling model for the formation of a topographic neural map

Article Abstract:

A quantitative model for the development of one arm of this map-the wiring of the nasal-temporal axis of the retina to the caudal-rostral axis of the superior colliculus is presented. Molecular genetic experiments, exploiting a combinatorial series of EphA receptor knock-in and knockout mice, confirm the salient predictions of the model, and show that it both describes and predicts topographic mapping.

Science & research, Mice, Mice (Rodents), Retina, Molecular genetics

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