Regioselective one-pot protection of carbohydrates

Article Abstract:

A combinatorial and highly-regioselective method is used for protecting individual hydroxy groups of a monosaccharide. Many building blocks are prepared starting from D-glucose and the iterative coupling of these building blocks has helped in assembling [beta]-1,6-glucans and a library of oligosaccharides based on the influenza-virus-binding trisaccharide.

Methods, Organic compounds, Organic compound synthesis

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Chemical glycosylation in the synthesis of glycoconjugate antitumour vaccines

Article Abstract:

An overview of selected glycosylation processes and strategies applied to the synthesis of tumour-associated carbohydrate antigens (TACA) and immunoadjuvants is presented. The advances in chemical glycosylation allow organic synthesis to fulfill its role as a supplier of rare carbohydrate antigens identified as potential targets for cancer immunotherapy.

Analysis, Glycosylation, Antineoplastic antibiotics

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How a T cell sees sugar

Article Abstract:

The crystal structure of an [alpha][beta]-T-cell receptor bound to a glycolipid antigen that is in a complex with a CD1 protein rotates clockwise from its classical position to make contact with antigen and recognize the carbohydrates.

Glycolipids, T cells, Structure

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