Renewing embryonic stem cells

Article Abstract:

A reliable method for growing embryonic stem (ES) cells that does not depend on animal-derived product was discovered by using high-throughput screening to produce a chemical that allows ES cells to perpetuate themselves. This chemical compound named SC1 was designed to target kinase enzymes, which pass on signals inside the cell and tested in mouse ES cells that were engineered to produce green fluorescent proteins (GFP) only when they were perpetuating themselves.

Protein kinases, Embryonic stem cells

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RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels

Article Abstract:

The mechanism of action of the selective anti-tumour agent erastin, involving the RAS-RAF-MEK signalling pathway demonstrate that ligands to voltage-dependent anion channels (VDACs) proteins could induce non-apoptotic cell death selectively in some tumour cells harbouring activation mutations in the RAS-RAF-MEK pathways.

United States, Health aspects, Analysis, Gene mutations, Gene mutation, Cancer cells, Ion channels, Antitussive agents

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Dressed-up proteins

Article Abstract:

The strategies that offer precise control over the attachment of carbohydrates and other post-translational modification (PTM)-mimics to polypeptides are described. The approach helped to bring together several chemical tools to obtain pure proteins carrying specific, complex-carbohydrate-based PTMs.

Polypeptides, Protein research

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