Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons

Article Abstract:

The class IV POU domain transcription factor, Brn-3.0, and the related factors Brn-3.1 and Brn-3.2 are involved in the survival and development of specific mammalian motor and sensory neurons. Brn-3.0 is crucial in the development of inferior olive, red nucleus, sensory ganglia and nucleus ambiguus. Homologous null mice Brn-3.0(super -/-) show physiological and behavioral defects. These show that the death of sensory and motor neurons is due to some aspects of neurotrophin-mediated signalling, and Brn-3.0 is involved in programmed gene expression, cell migration and neuron survival.

Physiological aspects, Genetic regulation, Genetic transcription, Transcription (Genetics), Neurons

---

Molecular basis of the little mouse phenotype and implications for cell type-specific growth

Article Abstract:

A mutation in growth hormone releasing factor (GRF) receptor of the dwarf mouse 'little' alters Asp 60 to Gly, reducing cyclicAMP levels; this is the molecular basis for the phenotype. The regulatory strategy this reveals for growing diverse cell types in a single organ seems to be common to many mammalian organs. The shift in growth factor usage permits signal transduction pathways to regulate different sets of genes.

Models, Phenotype, Phenotypes, Somatotropin releasing hormone, Somatotropin-releasing hormone

---

Eya protein phosphatase activity regulates six1-Dach-Eya transcriptional effects in mammalian organogenesis

Article Abstract:

Genetic interactions between sine oculis (Six) and eyes absent (Eya) factors that regulate precursor cell proliferation and survival during mammalian organogenesis are discussed. It is reported that Six1 is required for the development of murine kidney, muscle and inner ear, and that exhibits srynergistic genetic interactions with Eya factors.

United States, Influence, Organogenesis

Similar abstracts:

• Abstracts: Sex differences in provisioning rules and honest signaling of need in Manx shearwaters, Puffinus puffinus. Food-provisioning behaviour of male and female Manx shearwaters, Puffinus puffinus
• Abstracts: Questions for Clinton's inauguration. Clinton plans offer hints of technology agenda. Clinton emphasizes technology over science in choosing advisers for presidential campaign
• Abstracts: Sulfate supplementation of Angora goats: metabolic and mohair responses. Dietary protein level and ruminal degradability for mohair production in Angora goats
• Abstracts: Direct observation of single kinesin molecules moving along microtubules. Chemomechanical cycle of kinesin differs from that of myosin
• Abstracts: Identification and characterization of the vesicular GABA transporter. Defective recycling of synaptic vesicles in synaptotagmin mutants of Caenorhabditis elegans

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.