Role of the histone deacetylase complex in acute promyelocytic leukaemia
Article Abstract:
Oncogenic RARs appear to use abberrant chromatin acetylation to mediate leukaemogenesis. One way of treating the disease in humans may be to manipulate nuclear receptor co-factors using pharmacological methods. There are links between chimaeric receptors and the histone deacetylase complex, and this helps to explain the responses of patients to retinoids, as well as the way that APL develops. Histone deacetylase inhibitors increase differentiation of RA-sensitive induced by retinoids, and bring back retinoid responses of APL cell lines that are RA-resistant.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines
Article Abstract:
The yeast transcriptional adaptor, Gcn5p selectively acetylates histones H3 and H4 at specific lysines in the amino-terminal domains. Acetylation occurs at the lysine 14 of H3 and at lysines 8 and 16 of H4. Newly formed yeast H3 prefers acetylation at lysine 9. Gcn5p also acetylates lysines 5 and 12 in H4 during chromatin assembly of several organisms. The set of lysines acetylated by Gcn5p do not overlap with the sites generally used by the type B histone acetyltransferases for histone deposition and chromatin assembly.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A
Article Abstract:
CBP histone acetyltransferase (HAT) activity has been measured in cells subject to serum starvation. Induced HAT activity did not relate to accumulation of the protein. Investigations were undertaken to determine whether phosphorylation of CBP could induce enzymatic activation. CBP is found to be controlled by phosphorylation at the G1/S boundary, raising histone acetyltransferase activity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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