PAR3 is a cofactor for PAR4 activation by thrombin

Article Abstract:

It has been established that mouse PAR3 is a cofactor for mouse PAR4 cleavage and activation by thrombin. PAR3's cofactor function in mouse platelets indicates that G-protein-coupled receptors can act as accessory molecules that encourage the ligation of other G-protein-coupled receptors.

G proteins, Blood platelets, Platelet activation

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Role of thrombin signalling in platelets in haemostasis and thrombosis

Article Abstract:

The role of platelets is examined in detail. They have an important function in conditions relating to abnormal clotting, and thrombin signalling is a key factor.

Blood, Hemostasis

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Protease-activated receptor 3 is a second thrombin receptor in humans

Article Abstract:

The coagulation protease thrombin activates leukocytes, platelets, mesenchymal and endothelial cells at sites of vascular damage. They are partially activated by a proteolytically activated G-protein-coupled receptor. A new human thrombin receptor, termed protease-activated receptor 3, has been cloned and characterized. It is expressed in a number of tissues, including mouse megakaryocytes and human bone marrow, making it important in the understanding of thrombin signalling.

Proteases, Cell receptors

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