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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

Article Abstract:

The human cytomegalovirus (HCMV) genome encodes proteins that are transferred from the endoplasmic reticulum (ER) to the proteasome for destruction, the process involving Sec61 complex. The HCMV gene US2 specifies a product that induces synthesized major histocompatibility complex (MHC) class I molecules to be transported from the ER into the cytosol where they are deglycosylated. The deglycosylated breakdown intermediate is associated with the Sec61 complex, showing that retrograde transport occurs. After deglycosylation, they are degraded by the proteasome.

Author: Mothes, Walther, Rapoport, Tom A., Ploegh, Hidde L., Tortorella, Domenico, Jones, Thomas R., Bogyo, Matthew, Wiertz, Emmanuel J.H.J., Yu, Joyce
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
Viral genetics

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A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

Article Abstract:

An important physiological adaptation to endoplasmic reticulum(ER) stress is the elimination of misfolded proteins from the ER by retro-translocation. The identification of a membrane protein complex that provides the link to the process is reported.

Author: Rapoport, Tom A., Ron, David, Ye, Yihang, Shibata, Yoko, Yun, Chi
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
United States, Science & research, Translocation (Genetics), Translocations (Genetics)

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Subjects list: Research, Endoplasmic reticulum, Membrane proteins
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