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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

Article Abstract:

The increased expression of PNC1 (pyrazinamidase/nicotinamidase 1), which encodes enzyme for deamination of nicotinamide, are necessary for lifespan extension by calorie restriction and low-intensity stress are investigated. The mechanism of PNC1 in regulating longtivity and activating Sir2 are analyzed.

Author: Bitterman, Kevin J., Medvedik, Oliver, Sinclair, David A., Wood, Jason G., Anderson, Rozalyn M.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
Calories, Health aspects, Longevity, Niacinamide

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Sirtuin activators mimic caloric restriction and delay ageing in metazoans

Article Abstract:

Restricting caloric intake in metazoans can extend the lifespan of numerous species. Lifespan extension in budding yeast Saccharomyces cerevisiae is dependant on functional Sr2.

Author: Lavu, Siva, Wood, Jason G., Howitz, Konrad, Rogina, Balnka, Helfand, Stephen L., Tatar, Marc, Sinclair, David
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
United States, Metazoa, Metazoans, Life spans (Biology), Life span (Biology)

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Subjects list: Research, Brewer's yeast, Saccharomyces cerevisiae
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