Structural basis for inhibition of the replication licensing factor Cdt1 by geminin

Article Abstract:

tGeminin and tCdt1 are used for describing the crystal structure of the mouse geminin-Cdt1 complex. The crystal structure and the data collected suggests that the N-terminal region of tGeminin might be required for anchoring tCdt1 and the access of MCM complex to tCdt1 through steric hindrance is prevented by the C-terminal region of the tGeminin.

United States, Crystal structure

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A destructive switch for neurons

Article Abstract:

The triggering mechanism within neuroblasts that stop the cell-division cycle and trigger the activation of the programme that extends the axon is studied. The results of the study open a new link between the mechanism that causes the cell to cease division and the activation of the gene-expression programme that directs neuronal function.

United Kingdom, Gene expression, Neurons

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Centre- surround inhibition among olfactory bulb glomeruli

Article Abstract:

The so called 'short axon' cells sending interglomerular axons over long distances to from excitatory synapses with inhibitory periglomerular neurons up to 20- 30 glomeruli away is shown. Interglomerular excitation of these periglomerular cells potently inhibits mitral cells and forms an on centre, off surround circuit.

Kidney glomerulus, Glomeruli

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