Abstracts » Zoology and wildlife conservation

Structure and ligand of a histone acetyltransferase bromodomain

Article Abstract:

The bromodomains contained in almost all known histone-acetyltransferase-associated transcriptional co-activators seem to be acetyl-lysine-binding domains. They are therefore the first protein modules to show such interactions. The bromodomain/acetyl-lysine recognition could control protein-protein interactions by lysine acetylation. Bromodomain-acetyl-lysine binding could also play a significant role in the assembly and activity of multi-protein complexes in transcriptional activation.

Carrier proteins, Transport proteins, Genetic transcription, Transcription (Genetics)

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Helices sculpt membrane

Article Abstract:

Specialized 'coat' proteins wrap up a small area of the lipid membrane, shaping it into a bulging 'bud' and gathers the proteins due to be transported inside and the bud detaches from the membrane a stage called fission to form a bubble-like 'vesicle' loaded with cargo. This structure initiates buds of one type vesicle by thrusting one of its helices into the membrane, causing it to look like balloon.

United States, Science & research, Analysis, Proteins, Protein structure, Lipid membranes

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