Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors
Article Abstract:
The lysis of abnormal cells deficient in class I major histocompatibility complex (MHC) expression, by natural killer (NK) cells, provides a defence against pathogens and tumour cells. The MHC molecules of normal cells are recognized by NK-cell inhibitory receptors, and escape lysis. The X-ray structure of the p58 NK-cell inhibitory receptor clone 42 was determined at the 1.7-A resolution. The domain topology and their arrangement relative to each other show a link with the haematopoietic receptor family.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Viral decoy vetoes killer cell
Article Abstract:
Viruses avoid destruction by T cells through masking their presence by not expressing major histocompatibility complex (MHC) molecules. However, natural killer (NK) cells destroy any cells that do not express MHC molecules. Some viruses, including cytomegalovirus, have been found to evade detection and destruction by natural killer (NK) cells as well by adopting a decoy approach and expressing a homologue of normal MHC molecules.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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The footprint of a killer
Article Abstract:
Research into the structural nature of a life-saving link between a human major histocompatibility complex (MHC) molecule and its receptor on a natural killer cell is discussed. This research describes the structure of an immunoglobulin-type receptor, KIR2DL2, in complex with its MHC class I ligand, HLA-Cw3.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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