Synthetic lethal screen identification of chemosensitizer loci in cancer cells

Article Abstract:

A combination of a screening platform with a synthetic library of RNAs is used for a paclitaxel-dependent synthetic lethal screen that is designed to identify various gene targets that reduce the cell viability in the presence of sublethal concentrations of paclitaxel. The analysis reveals that most of such targets sensitize lung cancer cells, as several mechanistic relationships exist between the cancer-associated gene expression programs, as well as the basic cellular machinery required in the progression.

Science & research, Genetic aspects, Cancer cells, Lethal mutation, Paclitaxel, Structure

---

When the junk isn't junk

Article Abstract:

Introns have been considered examples of 'junk DNA,' a description for chromosomal sequences having no apparent function. This view was shattered by results of a cloning project aimed at sequencing the mouse UHG. UHG was found to be an example of an 'inside-out' gene wherein only introns encode function. The UHG structure is not believed to be unique, so further research could reveal other conserved intronic sequences.

Introns

---

Failure of B-cell differentiation in mice lacking the transcription factor EBF

Article Abstract:

Targeted gene disruption in mice revealed that the early B-cell factor (EBF) is essential for the generation of immunoglobulin expressing B cells. The results indicate a major role for EBF in the transcriptional regulation of B-cell differentiation in a step which lies between the immunoglobulin gene rearrangement step and the step in which commitment of cells to the B-lymphoid lineage occurs.

Genetic regulation, Genetic transcription, Transcription (Genetics), B cells, Cell differentiation

Similar abstracts:

• Abstracts: The motivation of non-nutritive sucking in calves, Bos taurus. Exploration in the pig may not be endogenously motivated
• Abstracts: The adaptive significance of colonial nesting in a coral-reef fish
• Abstracts: Song types and their structural features are associated with specific contexts in the banded wren. Caste-specific differences in risk sensitivity in honeybees, Apis mellifera
• Abstracts: Sheep self - medicate when challenged with illness - inducing foods
• Abstracts: Induction of an illusionary shadow person. Exploitation of structural and regulatory diversity in glutamate racemases

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.