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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

Article Abstract:

The hypothesis that additional proteins might exist in the presenilin complexes is supported by the fact that enzymatically active complexes have a mass that is much greater than predicted for a 1:1:1:1 stoichiometric complex. The TMP21, a member of the p24 cargo protein family, is a component of presenilin complexes and differentially regulates gamma-secretase cleavage without affecting epsilon-secretase activity.

Author: Tandon, Anurag, Rogaeva, Ekaterina, Fraser, Paul, Kawarai, Toshitaka, Hasegawa, Hiroshi, Westaway, David, Marambaud, Philippe, Schmitt-Ulms, Gerold, Hansen, Kirk, Fusheng Chen, Bohm, Christopher, Katayama, Taiichi, Yongjun Gu, Sanjo, Nobuo, Glista, Michael, Wakutani, Yosuke, Pardossi-Piquard, Raphaelle, St. George-Hyslop, Peter, Xueying Ruan, Checler, Frederic
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
Analysis, Protein research, Affinity labeling

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Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance

Article Abstract:

An aptamer displacement screen is used to identify SecinH3, a small molecule antagonist of cytohesins. Cytohesin inhibition has resulted in hepatic insulin resistance and hence their function might be crucial for regulating the sensitivity of insulin-responsive tissues.

Author: Kremmer, Elisabeth, Famulok, Michael, Hafner, Markus, Schmitz, Anton, Grune, Imke, Srivatsan, Seergazhi G., Paul, Bianca, Kolanus, Waldemar, Quast, Thomas, Bauer, Inga
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
Germany, Health aspects, Golgi apparatus, Insulin resistance, Hepatic agents

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and Beta APP processing

Article Abstract:

A transmembrane glycoprotein, nicastrin, is believed to modulate presenilin-mediated notch/glp-1 signal transduction and beta APP processing.

Author: Aebersold, Ruedi, Yu, Gang, Nishimura, Masaki, Arawaka, Shigeki, Levitan, Diane, Zhang, Lili, Tandon, Anurag, Song, You-Qiang, Rogaeva, Ekaterina, Chen, Fusheing, Kawari, Toshitaka, Supala, Agnes, Levesque, Lyne, Yu, Haung, Yang, Dun-Sheng, Holmes, Erin, Milman, Paul, Liang, Yan, Zhang, Dong Mei, Xu, Dong Hong, Sato, Christine, Rogaev, Evgeny, Smith, Marsha, Janus, Christopher, Zhang, Yanni, Farrer, Lindsay, Sorbi, Sandro, Bruni, Amalia, Fraser, Paul, St George-Hyslop, Peter
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
Glycoproteins

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Subjects list: Research, Cellular proteins
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