TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity
Article Abstract:
The hypothesis that additional proteins might exist in the presenilin complexes is supported by the fact that enzymatically active complexes have a mass that is much greater than predicted for a 1:1:1:1 stoichiometric complex. The TMP21, a member of the p24 cargo protein family, is a component of presenilin complexes and differentially regulates gamma-secretase cleavage without affecting epsilon-secretase activity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance
Article Abstract:
An aptamer displacement screen is used to identify SecinH3, a small molecule antagonist of cytohesins. Cytohesin inhibition has resulted in hepatic insulin resistance and hence their function might be crucial for regulating the sensitivity of insulin-responsive tissues.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and Beta APP processing
Article Abstract:
A transmembrane glycoprotein, nicastrin, is believed to modulate presenilin-mediated notch/glp-1 signal transduction and beta APP processing.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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