Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
Article Abstract:
A study conducted shows that BRCA1 or BRCA2 dysfunction unexpectedly and profoundly sensitizes cells to the inhibition of PARP enzymatic activity. This results into chromosomal instability, which in turn causes cell cycle arrest and finally apoptosis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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The tumour suppressor CYLD negatively regulates NF-(kappa)B signalling by deubiquitination
Article Abstract:
Research has been conducted on NF-(kappa)B transcription factors. The authors report that tumour suppressor CYLD which is mutated in familial cylinreomatosis interacts with I(kappa)B kinase-gamma, the regulatory subunit of I(kappa)B kinase.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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CYLD is a deubiquitinating enzyme that negatively regulates NF-(kappa)B activation by TNFR family members
Article Abstract:
Research has been conducted on CYLD protein. The authors have demonstrated that this protein is a deubiquitinating enzyme which regulates negatively transcription factor NF-(kappa)B activation via specific tumour-necrosis factor receptors.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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