Taxol found on tubulin

Article Abstract:

The use of technically advanced electron crystallography enabled the production of new images of taxol-bound tubulin sheets which are comparable to images obtained via X-ray crystallography or multidimensional nuclear magnetic resonance imaging. Electron crystallography will enhance scientists' capacity to obtain images of the binding of drug molecules to their target proteins. One potential application is in studies of the way potential antitumor drugs bind to tubulin, which has a key role in the movements of chromosomes during mitosis.

Usage, Crystallography, Binding sites (Biochemistry), Active sites (Biochemistry), Tubulins, Tubulin

---

Structural polymorphism of bacterial adhesion pili

Article Abstract:

Minute bacterial adhesion pili are formed by the tight winding of very thin structures. The pili are used for binding and maintaining the attachment of bacteria and target cells. The pili are capable of unraveling without undergoing depolymerization as they produce thin and long, extended structures to maintain their attachment to the lost cells. This enables the bacteria with pili to remain in the body of the host, while other bacteria are removed during the flow of urine.

Bacteria, Polymorphism (Zoology)

---

Cancer drugs better than taxol?

Article Abstract:

Scientists led by K.C. Nicolaou are synthesizing epothilone compounds for potential applications in cancer chemotherapy. These cytotoxic compounds, which are produced from a strain of the 'Sorangium cellulosum,' are expected to provide better cancer-treating properties compared with taxol. Epothilones work by promoting the creation of stable bundles of microtubules and preventing microtubule disassembly.

Cancer, Chemotherapy, Taxol

Similar abstracts:

• Abstracts: Structural biology: Molecular machinery in action. Structure and mechanism of the M2 proton channel of influenza A virus
• Abstracts: Three-dimensional structure of a tubulin-motor-protein complex. Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin
• Abstracts: Plans for Russian uranium payments stir fears of nuclear proliferation. Refusenik researchers return
• Abstracts: Green light for Golgi traffic. Homotypic vacuolar fusion mediated by t- and v-SNAREs. A SNARE-like protein required for traffic through the Golgi complex
• Abstracts: A keener eye than EGRET. In line for a new mission. Impact consensus emerges

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.