The complete genome sequence of the gastric pathogen Helicobacter pylori

Article Abstract:

It has been possible to make a whole-genome analysis of Helicobacter pylori, a micro-aerophilic, Gram-negative, slow-growing, flagellated and spiral-shaped organism. Valuable information has been obtained about this organism's antigenic variation, microaerophilic character, acid tolerance and pathogenesis. The gene content of H. pylori indicates that the basic methods of cell division, replication and secretion are similar to those of E. coli and H. influenzae. However, there are also significant differences, including the fact that the H. pylori genome does not have orthologues of DnaC, MinC and the secretory chaperonin SecB.

Genetic aspects, Chromosome mapping, Helicobacter pylori

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Introns in sequence tags

Article Abstract:

Standard cloning artefacts in some expressed sequence tags (EST) will affect the National Institutes of Health's (NIH) plans to patent genes identified during genome research. Analysis of the data indicate that many complementary DNA (cDNA) sequences are not actually genomic; patents may have to be reserved for better-defined clones. However, the alternative view is that library contamination by genomic DNA is too infrequent to hinder identification of cDNA clones. NIH patent applications are intended to protect the patentability of products derived from cDNA clones.

Intellectual property, United States. National Institutes of Health, Introns, Antisense DNA

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The first genome from the third domain of life

Article Abstract:

The first entire sequence of a eukaryotic organism, Saccharomyces cerevisiae, a yeast, is illustrated in the Yeast Genome Directory. The directory compares the genetic map of S. cerevisiae with the physical map of the nucleotide sequence. The yeast genome project had previously been criticsed for the use of non-automated technology, but the S. cerevisiae genome is now seen as indispensable for detailed cellular gene function analysis. It puts within reach whole genome comparisons covering Eukarya, Eubacteria and Arcaea.

Saccharomyces

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