The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

Article Abstract:

A mouse model in which p53 status could be reversibly switched in vivo between the functional and inactive states is used to demonstrate that the p53-mediated pathological response to whole-body irradiation, a prototypical genotoxic carcinogen, is irrelevant for suppression of radiation-induced lymphoma. In contrast, delaying restoration of p53 function untill the acute radiation response has subsided abrogates all of the radiation-induced pathology yet preserves most of the protection from lymphoma.

Author: Chrisophorou, M.A., Ringhausen, I., Finch, A.J., Swigart, L. Brown, Evan, G.I.
Causes of, DNA damage, Apoptosis

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


A constraint on canonical quantum gravity?

Article Abstract:

If the effects of quantum gravity are linearly proportional to the ratio of the photon energy, then the polarization of photons with energies of about 0.1 MeV should be completely random. Quantum gravity effects act with a power when the polarization measurement are confirmed.

Author: Mitrofanov, Igor G.
Quantum gravity

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


A faint population of bursts?

Article Abstract:

The estimates of energy from gamma ray bursts (GRB) ranges variably. 'Swift,' a new GRB mission, will be launched in October by the National Aeronautics and Space Administration (NASA) to detect more of faint bursts.

Author: Woosley, Stan
Space Research and Technology, Natl Aeronautics & Space Admin, United States. National Aeronautics and Space Administration, Space research, Beam optics

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Subjects list: Research, Gamma rays
This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.