The structural basis of specific base-excision repair by uracil-DNA glycosylase

Article Abstract:

A structural study of uracil-DNA glycosylase (UDGases) indicates that DNA base exclusion and binding interactions of uracil lead to the specific base-excision repair by UDGases. Base-excision proceeds through a catalytic pathway, as revealed by the presence of conserved residues near the uracil binding site. DNA-binding site determination and uracil identification in DNA are facilitated by complexes with a trideoxynucleotide and uracil.

Analysis, DNA repair, Binding sites (Biochemistry), Active sites (Biochemistry)

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Industrial biocatalysis today and tomorrow

Article Abstract:

Research is presented describing the important steps being taken in the biocatalyst synthetic chemistry industry and the implications for chemical products in the future.

Chemical industry

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Improving enzymes by using them in organic solvent

Article Abstract:

Research is presented describing the study of enzyme-catalysed reaction when placed in organic solvent rather than the traditionally used aqueous media.

Usage, Observations, Chemical research, Organic solvents

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