That vaccine passes a trial

Article Abstract:

Colombian biochemist Manuel Patarroyo has developed an anti-malarial vaccine which was synthesized based on three blood-stage antigens linked by the dominant element of the sporozoite antigen. The vaccine, called SPf66, has passed critically controlled trials where it has been shown to be 77% protective in children one to four years old. Although the degree of protection conferred by SPf66 is not dramatic, it may still be improved by adding new components. Furthermore, even partial protection against malaria will be effective in reducing the incidence of the disease.

Care and treatment, Testing

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Getting into the liver

Article Abstract:

The circumsporozoite protein that covers the sporozoite or infective stage of the malaria parasite functions as a ligand that attaches to receptors on the host hepatocytes or liver cells. Victor Nussenzweig and co-workers examined the frozen sections of different infected tissues to determine the pathological role of this protein, a problem that has long vexed malariologists. This protein may now become the focus of efforts to produce a vaccine for malaria.

Research, Physiological aspects, Sporozoa

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