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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Visualization of transient encounter complexes in protein-protein association

Article Abstract:

Paramagnetic relaxation enhancement was used to demonstrate the existence and visualize the distribution of an ensemble of transient, non-specific encounter complexes under equilibrium conditions for a relatively weak protein-protein complex between the amino-terminal domain of enzyme I and the phosphocarrier protein HPr. Restrained rigid-body simulated annealing refinement against the paramagnetic relaxation enhancement data enables to obtain an atomic probability distribution map of the non-specific encounter complex ensemble that qualitatively correlates with the electrostatic surface potentials on the interacting proteins.

Author: Iwahara, Junji, Clore, G. Marius, Tang, Chun
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
Maryland, Analysis, Carrier proteins, Transport proteins, Electrostatics, Amino acids, Structure, Chemical properties, Protein-protein interactions

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Life as we know it

Article Abstract:

The article focuses on segments of 'ultraconserved' DNA-sections that have stayed exactly same throughout recent vertebrate evolution and they are identical in humans, rats and mice.

Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Biological Product (except Diagnostic) Manufacturing, Drugs, Deoxyribonucleic Acid, Genetic aspects, DNA, Natural history, Vertebrates

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