Voltage-dependent modulation of N-type calcium channels by G-protein beta-gamma subunits
Article Abstract:
G-protein beta-gamma subunits regulate voltage-dependent inhibition of N-type Ca2+ channels induced by noradrenaline. Whole-cell Ca2+ currents are recorded from isolated neurons expressing N-type Ca2+ channels. Results show that transient overexpression of G-protein beta-gamma subunit in sympathetic neurons simulate and inhibits voltage-dependent Ca2+ channel activity. When stimulated with depolarizing voltage Ca2+ currents increase to a peak and then decreases slowly. G-protein alpha-subunits have negligible influence on the regulation of inhibition process.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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T-type calcium channel regulation by specific G-protein beta(sub)gamma subunits
Article Abstract:
Research indicaes that G-protein beta(sub)2gamma(sub)2 subunits selectively inhibit alpha(sub)1H low-voltage-activated calcium channels by binding to an intracellular loop connecting transmembrane domains II and III. Results show that reduction of channel activity by beta(sub)gamma is independent of voltage and alpha(sub)1H channel is an effector for G-protein beta(sub)gamma subunits.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells
Article Abstract:
The study investigates TRP ion channels as candidates and finds a TRPA1 that meets criteria for the transduction channel. It concluded that TRPA1 mRNA appears in the inner ear coincident with the onset of mechano-transduction, that antibodies to TRPA1, co-localize with the transduction apparatus, and that disruption of TRPA1 in zebrafish and mouse inhibits hair-cell transduction.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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