Ways around rejection

Article Abstract:

A study conducted on transgenic mice demonstrates the ways of survival of mismatched grafts of mouse testes that express the ligand for CD95 and those of the rejection of grafts taken from gld-donors that lack functional CD95 ligand. Mismatched grafts of other tissues are recognized by the host's immune system and are rejected by cytotoxic T cells. The T cells which are stimulated by the presence of foreign tissues, express CD95, a cell-surface molecule which kills the foreign cells. Grafts which express the CD95 ligands may decrease the occurrence of graft rejection.

Observations, Ligands (Biochemistry), Genetically modified mice

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CD95 ligand in graft rejection

Article Abstract:

Bellgrau and colleagues misinterpreted the concept of CD95 ligand (CD95 L) in graft rejection. A baby hamster kidney fibroblast cell line expressing transfected human CD95L complementary DNA was transplanted into nude mice. The injection of anti-CD95L reversed the rejection of the ligand transfectant, indicating that CD95L induces the rejection. In vivo experiments indicate that granulocytes are involved in the rejection process. CD95L binds to neutrophils and stimulates their cytotoxic mechanism, causing acute graft rejection.

Ligands, Ligands (Chemistry)

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Prevention and reversal of renal allograft rejection by antibody against CD45RB

Article Abstract:

Monoclonal antibody MB23G2, raised against CD45RB protein, prevents renal allograft rejection in mice. Mice injected with MB23G2, the monoclonal antibody against CD45RB, have normal renal function after allografts. Treatment with the antibody for 4 days reverses acute rejection, and the mice develop a capacity to survive for their natural lifespan. Tolerance to rejection is related to changes in the tyrosine phosphorylation of T-cell substrates required for signal transduction, as CD45RB is a protein-tyrosine phosphatase.

Physiological aspects, Monoclonal antibodies, Homografts

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