c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption
Article Abstract:
The proto-oncogene c-Cbl is identified as a specific signalling pathway requiring expression of the c-Src gene for bone resorption. This was gleaned from the tyrosine-phosphorylation of c-Cbl in a Src-dependent manner in osteoclasts, where they colocalize on some vesicular structures. Both c-src and c-cbl antisense oligonucleotides inhibit in vitro bone resorption by osteoclast-like cells (OCLs). Moreover, tyrosine phosphorylation of c-CBL and the localization of c-Cbl-containing structures to the peripheral cytoskeleton are hampered in resorption-deficient c-src-OCLs and in wild-type OCLs treated with c-src antisense oligonucleotides.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
The SIL gene is required for mouse embryonic axial development and left-right specification
Article Abstract:
Axial midline defects are found in mice embryos without the early-response gene SIL. These embryos also show randomized cardiac looping and a block in midline Sonic hedgehog signalling. It is possible that the early onset and extended duration of nodal, lefty-2 and Pitx2 expression across the whole right lateral-plate mesoderm is the reason why heart looping is randomized in SIL mutants but not in Shh and lefty-1 mutants. This may also be why other mouse, zebrafish and human mutants have variable co-occurrence and severity of left-right abnormalities.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: May the force be with you. Growth of nanotubes for probe microscopy tips. Chemical identification of individual surface atoms by atomic force microscopy
- Abstracts: Length of tail streamers in barn swallows. Pulling the fly's leg. How 'bad genes' survive
- Abstracts: Seismicity and stress rotation in a granular model of the brittle crust. Long-period volcano seismicity: its source and use in eruption forecasting
- Abstracts: Glucagon-like peptide-1 and satiety. Life and death of a signal peptide
- Abstracts: Clearing of researcher in 'Baltimore affair' boosts demand for reforms