p53 and treatment of bladder cancer

Article Abstract:

Adjuvant chemotherapy which includes DNA-damaging agents has lowered by threefold the recurrence risks of patients with p53-altered tumors. It also raised their chances of survival by 2.6-fold. On the other hand, adjuvant chemotherapy did not provide any recurrence or survival benefit to patients with tumors that did not show p53 alterations. This implies that only patients having p53-altered tumors benefit from adjuvant chemotherapy.

Author: Cote, Richard J., Groshen, Susan, Jones, Peter A., Esrig, David, Skinner, Donald G.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
Physiological aspects, Cancer, Tumor suppressor genes, Letter to the Editor, Adjuvant chemotherapy, Bladder cancer

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Epigenetics in human disease and prospects for epigenetic therapy

Article Abstract:

The term 'epigenetics' describes all meiotically and mitotically heritable change in gene expression that is coded in DNA sequence. Explaining the whole bandwidth of epigenetic mechanisms will lead to a clearer understanding of human disease and direct therapeutic concepts into new directions.

Author: Jones, Peter A., Egger, Gerda, Liang, Gangning, Apricio, Ana
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
Epigenetic inheritance

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Expandable DNA repeats and human disease

Article Abstract:

The article explores the mechanisms of RNA (ribonucleic acid) and DNA (deoxyribonucleic acid) repeat expansions and replications which result in diseases in human beings.

Author: Mirkin, Sergei M.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Genetic research, DNA replication

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Subjects list: Research, United States, Genetic disorders
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