A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation

Article Abstract:

Mutations in mod(mdg4) enhance the effect of the suppressor of Hairy wing su(HW) protein by inhibiting the function of enhancers located on both sides of the su(HW)-binding region. This inhibition causes a variegated expression pattern, and mutation in mod(mdg4) act as a classical enhancers of position-effect variegation. The mod(mdg4) protein regulates the nature of the repressive effect of su(HW); in the absence of mod(mdg4) protein, su(HW) exerts a bidirectional silencing effect, whereas in the presence of mod(mdg4) the silencing effect is transformed into unidirectional repression.

Chromatin, Proteins, Variegation, Variegation (Botany)

---

Dominant effects of suppressor of Hairy-wing mutations on gypsy-induced alleles of forked and cut in Drosophila melanogaster

Article Abstract:

A study was conducted to examine the impact of Hairy-wing su(Hw) mutations on gypsy-induced alleles. These forked (f) and cut (ct) loci mutations are often recessive. However, su(Hw) dominates alleles f(super k), ct(super k) and ct(superMRpN30). Molecular analysis of the f allele shows that it is the product of an altered state of octamer-like repeat and su(Hw) product. Mutations for the other alleles also show a correlation between su(Hw) and octamers.

Suppression, Genetic, Suppressor mutation (Molecular genetics), Mutation (Biology), Mutation

---

The suppressor of Hairy-wing protein regulates the tissue-specific expression of the Drosophila gypsy retrotransposon

Article Abstract:

Examination of the function of suppressor of Hairy-wing (su(HW)) protein in gypsy expression in Drosophila melanogaster reveals that during development su(HW) functions as a positive activator of gypsy transcription. Spatial and temporal expression of gypsy requires few other sequences along with su(HW)-binding site. Zinc finger region and two other structural regions of su(HW) are important for the transcriptional regulation of gypsy.

Genetic regulation, Mutagenesis

Similar abstracts:

• Abstracts: The Drosophila mei-S332 gene promotes sister-chromatid cohesion in meiosis following kinetochore differentiation
• Abstracts: Comparison of contact angles and adhesion to hexadecane of urogenital, dairy, and poultry Lactobacilli: effect of serial culture passages
• Abstracts: Meiotic nondisjunction and recombination of chromosome III and homologous fragments in Saccharomyces cerevisiae
• Abstracts: An unusual genomic position effect on Drosophila white gene expression: pairing dependence, interactions with zeste, and molecular analysis of revertants
• Abstracts: Molecular and genetic analysis of unc-7, a Caenorhabditis elegans gene required for coordinated locomotion. Analysis of the Caenorhabditis elegans axonal guidance and outgrowth gene unc-33

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.