A FRET-based sensor reveals large ATP hydrolysis-induced conformational changes and three distinct states of the molecular motor myosin

Article Abstract:

Results show that cysteine engineering of the myosin molecule produces a large ~70 degree nucleotide-dependent angle change in the light chain of the binding region. Data indicate that the bound magnesium-ADP.Pi is involved in the adoption to prestroke states by myosin.

United States, Statistical Data Included, Physiological aspects, Proteins, Conformational analysis, Amino acids, Amino acid structure-activity relationships, Protein conformation

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Molecular motor take tension in stride

Article Abstract:

Analysis of single-molecule have shown how a wide variety of eukaryotic motor proteins sense and respond to tension. A description of single motor studies on dynein is presented enabling one to understand molecular mechanisms used by this unique machine.

Eukaryotes, Protein kinases

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The mechanism of myosin VI translocation and its load-induced anchoring

Article Abstract:

Myosin VI is thought to perform both roles as a transporter and an anchor. A mechanism of myosin VI stepping that predicts a regulation through load of the motor's roles as transporter and anchor is proposed.

Genetic regulation, Translocation (Genetics), Translocations (Genetics)

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