A chromodomain protein, Swi6, performs imprinting functions in fission yeast during mitosis and meiosis

Article Abstract:

A chromodomain protein, Swi6, has been found to carry out imprinting functions in fission yeast during meiosis and mitosis. It is involved in imprinting the mat locus. Its transient overexpression changes the epigenetic implant at the mat2/3 region and it stays bound to the mat2/3 interval through the entire cell cycle and seems to be itself a component of the imprint. It converts the expressed state to the silenced one heritably.

Meiosis

---

CENP-E as an essential component of the mitotic checkpoint in vitro

Article Abstract:

CENP-E, a microtubule-dependent motor protein that extends at least 100 nm from the surface of kinetochores, has been seen to be an essential component of the mitotic checkpoint in vitro. Xenopus egg extracts were studied to look into how CENP-E acts in establishing, maintaining and silencing the mitotic checkpoint. It was surprising that depletion of CENP-E brought failure to establish a checkpoint arrest when challenged with microtubule-depolymerizing agents.

Statistical Data Included, Genetic aspects, Xenopus, Spindle (Cell division), Spindle (Cytoplasm), Sister chromatid exchange

---

Similar abstracts:

• Abstracts: XKlp1, a chromosomal Xenopus kinesin-like protein essential for spindle organization and chromosome positioning
• Abstracts: Discoidin domain receptor 1 functions in axon extension of cerebellar granule neurons. Role of Unc51.1 and its binding partners in CNS axon outgrowth
• Abstracts: Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Combinatorial roles of the nuclear receptor corepressor in transcription and development

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.