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A genomic screen of autism: evidence for a multilocus etiology

Article Abstract:

A genomic screen of autism, the most severe of the pervasive developmental disorders, carried out using linkage analysis in 90 multiplex sibships with parents, for 98 independent affected sib pairs (ASPs), with follow-up in 49 other multiplex sibships with 50 ASPs is discussed, and evidence for a multilocus etiology is presented. Unaffected sibs were part of the analysis as well, and it was found that positional cloning of susceptibility loci by linkage analysis may be a very daunting task, so other approaches may be required.

Author: Spiker, Donna, Pingree, Carmen, Petersen, P. Brent, Kraemer, Helena C., Risch, Neil, Myers, Richard M., Cavalli-Sforza, L. Luca, Hallmayer, Joachim, Kalaydjieva, Luba, Lotspeich, Linda, Nouri, Nassim, Hinds, David, McCague, Patty, Dimiceli, Sue, Pitts, Tawna, Nguyen, Loan, Yang, Joan, Harper, Courtney, Thorpe, Danielle, Vermeer, Saritha, Young, Helena, Hebert, Joan, Lin, Alice, Ferguson, Joan, Chiotti, Carla, Wiese-Slater, Susan, Rogers, Tamara, Salmon, Boyd, Nicholas, Peter, McMahon, William, Wong, Dona L.
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1999
United States, Australia, Statistical Data Included, Usage, Chromosome mapping, Genetic disorders

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Linkage-disequilibrium mapping of autistic disorder, with 15q11-13 markers

Article Abstract:

Linkage-disequilibrium analysis of autistic disorder has pointed to marker GABRB3 155CA-2 (MTDT 28.63, 10 df, P = .0014) in the 15q11-13 region as a positional and functional candidate. GABRB3 is a gamma-aminobutyric acid (subA) receptor subunit gene. The region 15q11-13 is also critical for Prader-Willi/Angelman syndrome. The study involved 138 families, primarily composed of one child with autistic disorder and parents.

Author: Cook, Edwin H., Jr., Cox, Nancy J., Courchesne, Eric, Lord, Catherine, Lincoln, Alan, Leventhal, Bennett L., Courchesne, Rachel Y., Gonen, David, Guter, Stephen J., Nix, Kristi, Haas, Richard
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
GABA

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Subjects list: Research, Genetic aspects, Autism
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