A major T-cell-inducing cytosolic 23 kDa protein antigen of the vaccine candidate Mycobacterium habana is superoxide dismutase

Article Abstract:

Immunoblotting and SDS-PAGE studies reveal that the 23 kDa cytosolic protein antigen of the vaccine candidate Mycobacterium habana is superoxide dismutase (SOD). The 18 N-terminal amino acid sequence of the enzyme is similar to those of M. tuberculosis, M. leprae and human SODs. T cells of guinea-pigs and mice primed with M. habana recognize M. habana SOD. The enzyme also induces T lymphocyte proliferative responses similar to those induced by M. leprae in human tuberculoid leprosy patients and individuals exposed to environmental mycobacteria.

Superoxide dismutase, Tuberculosis vaccines, T cell proliferation

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Glutamate and cyclic AMP regulate the expression of galactokinase in Mycobacterium smegmatis

Article Abstract:

Experiments were performed to show that the ability of galactose to induce galactokinase (galK) in Mycobacterium smegmatis depends on the presence of glutamate at low concentration. While rifampicin inhibits the glutamate-mediated expression of galK in the presence or absence of galactose, extracellular cyclic adenosine monophosphate stimulates the expression of the enzyme in the presence of glutamate and galactose. Results indicate that two different promoters were involved in the expression of the galK gene.

Genetic regulation, Genetic transcription, Transcription (Genetics), Glutamate, Cyclic adenylic acid, Cyclic adenosine monophosphate, Rifampin, Galactose

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