A simple and improved correction for population stratification in case-control studies

Article Abstract:

Available approaches for controlling stratification by use of substructure-informative loci is not able to resolve the population stratification in case-control studies of disease-marker association hence, a new two-step procedure is proposed to address the issue. This two-step procedure approach yields a more appropriate correction for stratification than the principal components or genomic control.

United States, Quantitative trait loci

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Measuring European population stratification with microarray genotype data

Article Abstract:

The population structure in Europeans of known and unknown ancestry is explored using a report on genomewide typing of approximately 10,000 single-nucleotide polymorphisms in 297 individuals. The results show the presence of several significant axes of stratification, particularly in a northern-southeastern trend and also along an east-west axis.

Europe, Genetic aspects, Europeans, DNA microarrays

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An evaluation of power and type I error of single-nucleotide polymorphism transmission/disequilibrium-based statistical methods under different family structures, missing parental data, and population stratification

Article Abstract:

A simulation study design is used to compare the power and type I error of eight transmlssion/disequilibrium (TD)-based methods under different family structures, frequencies of missing parental data, genetic model and population stratifications. It is found that type I error is appropriate for every test statistic under all conditions.

Heredity, Human, Human heredity, Report

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