Abstracts - faqs.org

Abstracts

Biological sciences

Search abstracts:
Abstracts » Biological sciences

A tyrosine-based signal targets H/K-ATPase to a regulated compartment and is required for the cessation of gastric acid secretion

Article Abstract:

Researchers have investigated the role of a tyrosine-based sequence motif present in the cytoplasmic tail of the beta subunit of the H/K-ATPase in the targeting of this protein to a regulated compartment in vivo. This work involved mutagenizing the Tyr residue to Ala and producing transgenic mice expressing either the wild type or the mutagenized form of the H/K-ATPase beta subunit. It was established that the H/K-ATPase beta subunit tyrosine-based motif is required to prompt the removal of the H/K-ATPase from the apical membrane of parietal cells. The motif is also need to ensure that the H/K-ATPase is returned to the TVE compartment to stop the process of acid secretion.

Author: Kashgarian, Michael, Caplan, Michael J., Courtois-Coutry, Nathalie, Roush, Denise, Rajendran, Vanathy, McCarthy, J. Brian, Geibel, John
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
Adenosine triphosphatase, Tyrosine metabolism, Gastric acid

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Globin gene expression is reprogrammed in chimeras generated by injecting adult hematopoietic stem cells into mouse blastocysts

Article Abstract:

The differentiation capacity of adult hematopoietic stem cells (HSC) is investigated by injecting HSCs from adult mice into blastocysts. Results reveal that adult HSCs survive in mouse embryos, further, the erythroid line synthesized fetal globin proteins. Conversely, embryonic erythroid progenies synthesize adult globin proteins when injected to adult mice. HSCs from adult mice exhibit gene expression plasticity depending on the environment.

Author: Bonifer, Constanze, Muller, Albrecht M., Geiger, Hartmut, Sick, Stephanie
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
Gene expression, Hematopoietic stem cells, Globin genes, Hemoglobin synthesis

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA



Subjects list: Research, Physiological aspects, Mice, Mice (Rodents)
Similar abstracts:
  • Abstracts: The E. coli signal recognition particle is required for the insertion of a subset of inner membrane proteins. Dissecting RNA-protein interactions: RNA-RNA recognition by Rop
  • Abstracts: Energetics, thermoregulation and nocturnal hypothermia in Australian silvereyes
  • Abstracts: The alkene monooxygenase from Xanthobacter strain Py2 is closely related to aromatic monooxygenases and catalyzes aromatic monohydroxylation of benzene, toluene, and phenol
  • Abstracts: Enterobactin synthase polypeptides of Escherichia coli are present in an osmotic-shock-sensitive cytoplasmic locality
  • Abstracts: Microbial communities associated with anaerobic benzene degradation in a petroleum-contaminated aquifer. A novel PhosphorImager-based technique for monitoring the microbial reduction of technetium
This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.
Some parts © 2025 Advameg, Inc.