Cell migration: a physically integrated molecular process

Article Abstract:

Cell migration is crucial to the integration of molecular components in the cell such as adhesion molecules, ligands and linking proteins. It is also essential to several morphogenic processes such as neurology, immune response and metastasis. The ability to migrate is determined by the cells' spatial asymmetry and kinetic features such as the lamellipodia and filopodia. A connection between the biochemical signal transduction pathway and the attachments for locomotion is also required for cell migration.

Genetic aspects, Cells, Cell migration

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TRAP is necessary for gliding motility and infectivity of plasmodium sporozoites

Article Abstract:

Researchers have investigated the role of a surface protein called thrombospondin-related anonymous protein (TRAP) in the development of sporozoites and their interactions with host cells. This involved disrupting the TRAP gene in P. berghei. It was established that TRAP-like molecules may be central elements of motility and invasion machineries of Apicomplexa, along with the parasite actin network. It is possible that TRAP may be involved in a capping-like process during cell invasion.

Research, Causes of, Physiological aspects, Malaria, Parasitic diseases, Plasmodium, Plasmodium (Protozoa), Sporozoa

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