Activation of the protein kinase C1 pathway upon continuous heat stress in Saccharomyces cerevisiae is triggered by an intracellular increase in osmolarity due to trehalose accumulation

Article Abstract:

The accumulation of trehalose and the activation of the protein kinase C1 (PKC1) (cell integrity) pathway in both glucose- and ethanol-grown cells were analyzed upon temperature upshifts within the narrow range of growth temperatures. The results showed that under heat stress conditions the activation of the PKC1 pathway is triggered by an increase in intracellular osmolarity, due to the accumulation of trehalose, rather than by the increase in temperature.

Protein kinases, Structure, Heat exhaustion

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New insights into trehalose metabolism by Saccharomyces cerevisiae: NTH2 encodes a functional cytosolic trehalase, and deletion of TPS1 reveals Athp1-dependent trehalose mobilization

Article Abstract:

The studies have shown that NTH2, a paralog of NTH1, has encoded a functional trehalase that is implicated in trehalose mobilization by Saccharomyces. Glycogen is mobilized earlier and faster when the Ath1p-dependent mobilization of trehalose is impaired, indicating a fine-tuning control in carbon storage management during periods of carbon and energy restriction.

Glycogen, Cytosol, Chemical properties, Trehalose

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Recombinant Saccharomyces cerevisiae strain expressing a model cytochrome P450 in the rat digestive environment: Viability and bioconversion activity

Article Abstract:

A Recombinant Saccharomyces cerevisiae strain expressing plant is used as a model to study the role of cytochrome P450 in the digestive environment of a rat. The approach can be further used to develop new drug delivery systems based on yeast catalyzing a bioconversion reaction in the digestive tract.

Cytochrome P-450

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