Activity, expression and function of a second Drosophila protein kinase A catalytic subunit gene

Article Abstract:

The function, expression and activity of a second Drosophila protein kinase A (PKA) catalytic subunit gene, designated DC2, were investigated by expressing the proteins in bacteria and insect cells. Detailed molecular analysis showed that DC2 behaves as a PKA catalytic subunit in vitro and its expression depends on dorsal activity. Screening of a small interval containing DC2 for recessive lethal mutations failed to form DC2 alleles. Meanwhile, trans-heterozygotes mutants lacking DC2 activity were viable and fertile.

Cellular signal transduction, Protein kinases

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The embryonically active gene, unkempt, of Drosophila encodes a Cys(sub 3)His finger protein

Article Abstract:

A Cys(sub 3)His protein of Drosophila, designated unkempt, was identified and characterized. The gene encodes an abundant embryonic RNA whose expression becomes restricted to the central nervous system in stages 16 and early 17. Sequence analysis showed that the unkempt gene codes for five potential Cys(sub 3)His fingers. Mutation analysis shows that unkempt gene expression is not essential during embryonic development. However, its functionis required post-embryonically for larval or early pupal development.

Developmental biology, Embryology, Animal embryology

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Single amino acid exchanges in separate domains of the serendipity delta zinc finger protein caused embryonic and sex biased lethality

Article Abstract:

Four mutations in the Drosophila serendipity (sry) delta finger protein are characterized. The mutations, induced by ethyl methanesulfate, are all lethal mutations varying in their potencies which occur late in embryonic development, during the first larval instar or during pupation. Studies done on males escaping the lethal effects of the mutation indicate that the gene is essential either in the preservation of viability, normal gonadal development or both.

Lethal mutation

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