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Combining evidence of natural selection with association analysis increases power to detect malaria- resistance variants

Article Abstract:

The article describes a case 'control association study of malaria resistance. Results demonstrated that combining association analysis with evidence of natural selection could increase power to detect risk variants by order of magnitude.

Author: Patterson, Nick, Reich, David, Price, Alkes L., Ayodo, George, Orago, Alloys S. S., Keinan, Alon, Otieno, Michael F., Ajwang, Arthur
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
Analysis, Natural selection, Genetic variation

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Admixture mapping of white cell count: Genetic locus responsible for lower white blood cell count in the health ABC and Jackson Heart Studies

Article Abstract:

A survey was conducted on the entire genome for loci underlying the difference in white blood cell count (WBC) among African Americans using admixture mapping in the Health, Aging and Body Composition and Jackson Heart Studies.

Author: Zmuda, Joseph M., Harris, Tamara B., Ziv, Elad, Files, Joe C., Beamer, Brock A., Patel, Kushang V., Reich, David, Garcia, Melissa, Tandon, Arti, Huntsman, Scott, Rongling Li, Nalls, Michael A., Wilson, James G., Patterson, Nick J., Hu, Donglei, Akylbekova, Ermeg L., Hardy, Cheryl L., Buxbaum, Sarah G., Taylor, Herman A.
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2008
Science & research, Health aspects, Aging, Research, African Americans, Genetic aspects, Aging (Biology), Blood cell count, White blood cell count

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