KSR: A novel player in the RAS pathway
Article Abstract:
The Caenorhabditis elegans kinase suppressor of RAS (ksr-1) gene is necessary for the activity of activated RAS. The KSR-1 kinase, encoded by ksr-1, is structurally similar to C. elegans RAF/LIN-45 and mammalian RAF. Loss of function in ksr-1 genes prevents the vulvaless phenotype caused by activated RAS. The Drosophila homolog of KSR-1 inhibits the activity of activated RAS while activated RAF is unaffected. Loss of function ksr-1 mutations are lethal in Drosophila. KSR-1 acts downstream or parallel to RAS and upstream to RAF and LIN-1, a transcription factor.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles
Article Abstract:
The mutation-caused failure in the functions of serine-threonine encoded by aurora (aur) leads to the disfunctiong of the centrosomes to separate and make a bipolar spindle. The aur is allelic to mutations and lies in the cytogenetic interval of 87A7-A9, which has eight transcription units. The syncytial embryos of the aur mother have closely paired centrosomes and interconnected spindles in wrong mitotic stages.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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